ANCA-negative pauci-immune crescentic glomerulonephritis

被引：0
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作者：
Min Chen
Cees G. M. Kallenberg
Ming-Hui Zhao
机构：
[1] Peking University First Hospital,Renal Division, Department of Medicine
[2] University Medical Center Groningen,Department of Rheumatology and Clinical Immunology
[3] University of Groningen,undefined
来源：
Nature Reviews Nephrology | 2009年 / 5卷
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摘要：
Pauci-immune crescentic glomerulonephritis is usually a manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. However, some patients with pauci-immune crescentic glomerulonephritis lack ANCA. This Review compares the prevalence, clinical manifestations, histopathology, and outcomes of ANCA-negative pauci-immune crescentic glomerulonephritis with that of ANCA-positive disease. The authors also discuss the possible pathogenesis of ANCA-negative pauci-immune crescentic glomerulonephritis, paying particular attention to the mechanisms and role of neutrophil activation.
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页码：313 / 318
页数：5
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