Synthesis and Alkylation of Diethyl 6-Aryl-2-Oxo-1,2,3,6-Tetrahydropyrimidine-4,5-Dicarboxylates

被引：0

作者：

M. A. Kolosov

M. J. K. Al-Ogaili

V. S. Parkhomenko

V. D. Orlov

机构：

[1] V. N. Karazin Kharkiv National University,

来源：

Chemistry of Heterocyclic Compounds | 2014年 / 49卷

关键词：

diethyl 2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates; oxalacetic ester; alkylation; Biginelli reaction;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We have demonstrated the preparation of diethyl 6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates by reaction of urea, oxalacetic ester, and aromatic aldehydes with substituents of various electronic properties. Alkylation of the obtained compounds in the alkyl halogenide–KOH/Н2О–MeCN system resulted in mixtures of N-alkyl derivatives, which can be separated by column chromatography. Longer reaction time led selectively to 1,3-dialkylation products.

引用

页码：1484 / 1489

页数：5

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