Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling

被引：0

作者：

Federica Simeoni

Luisa Tasselli

Shinji Tanaka

Lidia Villanova

Mayumi Hayashi

Kazuishi Kubota

Fujio Isono

Benjamin A. Garcia

Eriko Michishita-Kioi

Katrin F. Chua

机构：

[1] Gerontology and Metabolism,Department of Medicine, Division of Endocrinology

[2] School of Medicine,Department of Experimental Medicine

[3] Stanford University,Discovery Science and Technology Department

[4] Stanford,Department of Biochemistry and Biophysics

[5] California 94305,undefined

[6] USA,undefined

[7] Geriatric Research,undefined

[8] Education,undefined

[9] and Clinical Center,undefined

[10] VA Palo Alto Health Care System,undefined

[11] Palo Alto,undefined

[12] California 94304,undefined

[13] USA,undefined

[14] Frontier Research Laboratories,undefined

[15] Daiichi Sankyo Co.,undefined

[16] Ltd.,undefined

[17] 1-2-58 Hiromachi,undefined

[18] Tokyo 140-8710,undefined

[19] Japan,undefined

[20] Sapienza University,undefined

[21] Daiichi Sankyo RD Novare Co.,undefined

[22] Ltd.,undefined

[23] 1-16-13,undefined

[24] Kitakasai,undefined

[25] Tokyo 134-8630,undefined

[26] Japan,undefined

[27] University of Pennsylvania,undefined

[28] Philadelphia,undefined

[29] PA 19104,undefined

[30] USA,undefined

[31] Current address: Venture Science Laboratories,undefined

[32] Daiichi Sankyo Co.,undefined

[33] Ltd.,undefined

[34] 1-2-58 Hiromachi,undefined

[35] Tokyo 140-8710,undefined

[36] Japan.,undefined

来源：

Scientific Reports | / 3卷

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D O I：

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摘要：

The chromatin regulatory factor SIRT6 plays pivotal roles in metabolism, tumor suppression, and aging biology. Despite the fundamental roles of SIRT6 in physiology and disease, only a handful of molecular and functional interactions of SIRT6 have been reported. Here, we characterize the SIRT6 interactome and identify 80+ novel SIRT6-interacting proteins. The discovery of these SIRT6-associations considerably expands knowledge of the SIRT6 interaction network, and suggests previously unknown functional interactions of SIRT6 in fundamental cellular processes. These include chromatin remodeling, mitotic chromosome segregation, protein homeostasis, and transcriptional elongation. Extended analysis of the SIRT6 interaction with G3BP1, a master stress response factor, uncovers an unexpected role and mechanism of SIRT6 in regulating stress granule assembly and cellular stress resistance.

引用

共 25 条

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