Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

被引：0
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作者：
Francesca Finotello
Clemens Mayer
Christina Plattner
Gerhard Laschober
Dietmar Rieder
Hubert Hackl
Anne Krogsdam
Zuzana Loncova
Wilfried Posch
Doris Wilflingseder
Sieghart Sopper
Marieke Ijsselsteijn
Thomas P. Brouwer
Douglas Johnson
Yaomin Xu
Yu Wang
Melinda E. Sanders
Monica V. Estrada
Paula Ericsson-Gonzalez
Pornpimol Charoentong
Justin Balko
Noel Filipe da Cunha Carvalho de Miranda
Zlatko Trajanoski
机构：
[1] Medical University of Innsbruck,Biocenter, Division of Bioinformatics
[2] Medical University of Innsbruck,Division of Hygiene and Medical Microbiology
[3] Medical University of Innsbruck,Department of Haematology and Oncology
[4] Leiden University Medical Centre,Department of Pathology
[5] Vanderbilt University,Department of Medicine
[6] Vanderbilt University Medical Center,Department of Biostatistics
[7] Vanderbilt University Medical Center,Department Pathology Microbiology and Immunology
[8] Vanderbilt University Medical Center,Department of Medical Oncology and Internal Medicine VI, National Center for Tumor Diseases
[9] University Hospital Heidelberg,Division of Translational Immunotherapy
[10] German Cancer Research Center (DKFZ),undefined
[11] Austrian Drug Screening Institute,undefined
来源：
Genome Medicine | / 11卷
关键词：
Cancer immunology; Immunotherapy; Deconvolution; RNA-seq; Immune contexture;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data.
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