Hippo/Yap Signaling in Cardiac Development and Regeneration

被引：51

作者：

Xiao Y. ^{[1
,2
]}

Leach J. ^{[1
]}

Wang J. ^{[1
]}

Martin J.F. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, 77030, TX

[2] Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, 77030, TX

[3] Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, 77030, TX

[4] Baylor College of Medicine, One Baylor Plaza, Houston, 77030, TX

[5] Cardiovascular Research Institute, Baylor College of Medicine, Houston, 77030, TX

来源：

Current Treatment Options in Cardiovascular Medicine | 2016年 / 18卷 / 6期

关键词：

Cardiac development; Cardiac regeneration; Hippo/Yap signaling;

D O I：

10.1007/s11936-016-0461-y

中图分类号：

学科分类号：

摘要：

The heart has historically been considered to be a non-regenerative organ. Recent insights have suggested that cardiomyocytes have a small but measurable ability to regenerate. Moreover, recent work has also shown that manipulating the expression of specific genetic pathways can improve the ability of the heart to repair itself. These new insights set the stage for the development of new treatments for heart failure. © 2016, Springer Science+Business Media New York.

引用

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