Effects of haloperidol on sensory processing in the hippocampus during classical eyeblink conditioning

被引：0

作者：

L. L. Sears

Joseph E. Steinmetz

机构：

[1] Department of Pediatrics,

[2] University of Louisville,undefined

[3] 571 S. Floyd Street,undefined

[4] Suite 100,undefined

[5] Louisville,undefined

[6] KY 40202-3828,undefined

[7] USA,undefined

[8] Program in Neural Science and Department of Psychology,undefined

[9] Indiana University,undefined

[10] Indiana,undefined

[11] USA,undefined

来源：

Psychopharmacology | 1997年 / 130卷

关键词：

Key words Schizophrenia; Haloperidol; Classical conditioning; Sensory processing; Limbic system; Learning;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The rabbit classical eyeblink conditioning paradigm was used to assess the effects of haloperidol on hippocampal function. Haloperidol disrupted hippocampal activity and conditioned responses (CRs) at low but not high conditioned stimulus (CS) intensities. The observed relationship of hippocampal activity and the CR suggested that the hippocampus encoded sensory features associated with the learned response. Sensory processing by the hippocampus appeared to be altered by haloperidol through attenuation of the ability of a CS to evoke a learned response. Results are discussed in terms of the role of the hippocampus in sensory processing and possible mechanisms for the beneficial effects of haloperidol in schizophrenia. Classical eyeblink conditioning may provide a model system for studying behavioral and biological issues relevant to the etiology and treatment of schizophrenia.

引用

页码：254 / 260

页数：6

共 50 条

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