SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

被引：0

作者：

Constanze Schneider

Thomas Oellerich

Hanna-Mari Baldauf

Sarah-Marie Schwarz

Dominique Thomas

Robert Flick

Hanibal Bohnenberger

Lars Kaderali

Lena Stegmann

Anjali Cremer

Margarethe Martin

Julian Lohmeyer

Martin Michaelis

Veit Hornung

Christoph Schliemann

Wolfgang E Berdel

Wolfgang Hartmann

Eva Wardelmann

Federico Comoglio

Martin-Leo Hansmann

Alexander F Yakunin

Gerd Geisslinger

Philipp Ströbel

Nerea Ferreirós

Hubert Serve

Oliver T Keppler

Jindrich Cinatl

机构：

[1] Institute of Medical Virology,Department of Medicine II

[2] University of Frankfurt,Cambridge University Department of Haematology

[3] Hematology and Oncology,Department of Virology

[4] ,Department of Chemical Engineering and Applied Chemistry

[5] Goethe University of Frankfurt,Gene Center and Department of Biochemistry

[6] Cambridge Institute of Medical Research,Department of Medicine A (Hematology

[7] German Cancer Consortium partner site,undefined

[8] German Cancer Research Center,undefined

[9] Max von Pettenkofer Institute,undefined

[10] Ludwig Maximilian University of Munich,undefined

[11] Pharmazentrum frankfurt/ZAFES,undefined

[12] ,undefined

[13] Institute of Clinical Pharmacology,undefined

[14] Goethe University of Frankfurt,undefined

[15] University of Toronto,undefined

[16] Institute of Pathology,undefined

[17] University Medical Center,undefined

[18] Institute of Bioinformatics,undefined

[19] University Medicine Greifswald,undefined

[20] Centre for Molecular Processing and School of Biosciences,undefined

[21] University of Kent,undefined

[22] Institute of Molecular Medicine,undefined

[23] University Hospital Bonn,undefined

[24] Ludwig Maximilian University of Munich,undefined

[25] Oncology),undefined

[26] University Hospital Münster,undefined

[27] Gerhard Domagk Institute for Pathology,undefined

[28] University Hospital Münster,undefined

[29] Senckenberg Institute of Pathology,undefined

[30] University of Frankfurt,undefined

[31] Fraunhofer Institute for Molecular Biology and Applied Ecology (IME),undefined

[32] Project Group Translational Medicine and Pharmacology (TMP),undefined

来源：

Nature Medicine | 2017年 / 23卷

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D O I：

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学科分类号：

摘要：

The therapeutic response of acute myeloid leukemia to the nucleoside analog Ara-C is controlled by SAMHD1, an enzyme that hydrolyzes the active metabolite Ara-CTP.

引用

页码：250 / 255

页数：5

共 50 条

[1] SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
Schneider, Constanze
Oellerich, Thomas
Baldauf, Hanna-Mari
Schwarz, Sarah-Marie
Thomas, Dominique
Flick, Robert
Bohnenberger, Hanibal
Kaderali, Lars
Stegmann, Lena
Cremer, Anjali
Martin, Margarethe
Lohmeyer, Julian
Michaelis, Martin
Hornung, Veit
Schliemann, Christoph
Berdel, Wolfgang E.
Hartmann, Wolfgang
Wardelmann, Eva
Comoglio, Federico
Hansmann, Martin-Leo
Yakunin, Alexander F.
Geisslinger, Gerd
Stroebel, Philipp
Ferreiros, Nerea
Serve, Hubert
Keppler, Oliver T.
Cinatl, Jindrich, Jr.
NATURE MEDICINE, 2017, 23 (02) : 250 - 255
[2] Correction: Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
Constanze Schneider
Thomas Oellerich
Hanna-Mari Baldauf
Sarah-Marie Schwarz
Dominique Thomas
Robert Flick
Hanibal Bohnenberger
Lars Kaderali
Lena Stegmann
Anjali Cremer
Margarethe Martin
Julian Lohmeyer
Martin Michaelis
Veit Hornung
Christoph Schliemann
Wolfgang E Berdel
Wolfgang Hartmann
Eva Wardelmann
Federico Comoglio
Martin-Leo Hansmann
Alexander F Yakunin
Gerd Geisslinger
Philipp Ströbel
Nerea Ferreirós
Hubert Serve
Oliver T Keppler
Jindrich Cinatl
Nature Medicine, 2017, 23 : 788 - 788
[3] SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia (vol 23, pg 250, 2017)
Schneider, Constanze
Oellerich, Thomas
Baldauf, Hanna-Mari
Schwarz, Sarah-Marie
Thomas, Dominique
Flick, Robert
Bohnenberger, Hanibal
Kaderali, Lars
Stegmann, Lena
Cremer, Anjali
Martin, Margarethe
Lohmeyer, Julian
Michaelis, Martin
Hornung, Veit
Schliemann, Christoph
Berdel, Wolfgang E.
Hartmann, Wolfgang
Wardelmann, Eva
Comoglio, Federico
Hansmann, Martin-Leo
Yakunin, Alexander F.
Geisslinger, Gerd
Strobel, Philipp
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NATURE MEDICINE, 2017, 23 (06) : 788 - 788
[4] Evidence for SAMHD1 Tumor Suppressor Functions in Acute Myeloid Leukemia
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ACTA HAEMATOLOGICA, 2020, 143 (01) : 7 - 8
[5] SAMHD1 is a Novel Biomarker and Therapeutic Target for Radiation Therapy and PARP Inhibition
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[6] Repurposing Old Drugs as SAMHD1 Inhibitors to Improve Efficacy of Cytarabine in Paediatric Acute Myeloid Leukaemia
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[7] Targeting SAMHD1 Promotes Anti-Tumor Immunity in Acute Myeloid Leukemia
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[9] Expression and Relationship of SAMHD1 with Other Apoptotic and Autophagic Genes in Acute Myeloid Leukemia Patients
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[10] The Spliceosome As a New Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia
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BLOOD, 2021, 138

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