Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation

被引：0
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作者：
Jing Wang
Yanchun Ji
Cheng Ai
Jia-Rong Chen
Dingyi Gan
Juanjuan Zhang
Jun Q. Mo
Min-Xin Guan
机构：
[1] Zhejiang University School of Medicine,Center for Mitochondrial Biomedicine, The Fourth Affiliated Hospital
[2] Zhejiang University School of Medicine and National Clinical Research Center for Child Health,Division of Medical Genetics and Genomics, The Children’s Hospital
[3] Zhejiang University School of Medicine,Institute of Genetics
[4] Wenzhou Medical University,School of Optometry and Ophthalmology and Eye Hospital
[5] University of California at San Diego School of Medicine,Department of Pathology, Rady Children’s Hospital
[6] Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders,Key Lab of Reproductive Genetics, Ministry of Education of PRC
[7] Zhejiang University,undefined
来源：
Journal of Biomedical Science | / 30卷
关键词：
Leber’s hereditary optic neuropathy; Mitochondrial DNA mutation; Complex I; Allotopic expression; Apoptosis; Mitophagy;
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