Synthesis and Pharmacological Activity of C(2)-Substituted Benzimidazoles

被引：0
|
作者：
O. N. Zhukovskaya
A. A. Spasov
D. S. Yakovlev
V. A. Kosolapov
D. V. Mal’tsev
A. S. Morkovnik
V. A. Babkova
A. A. Brigadirova
Ya. V. Agatsarskaya
A. S. Taran
M. V. Miroshnikov
K. T. Sultanova
V. I. Kornilov
V. A. Anisimova
机构：
[1] Southern Federal University,Institute of Physical and Organic Chemistry
[2] Ministry of Health of the RF,Volgograd State Medical University
[3] Volgograd Medical Scientific Center,undefined
来源：
Pharmaceutical Chemistry Journal | 2019年 / 53卷
关键词：
benzimidazole; synthesis; serotonin receptor; antiglycation and antioxidant activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Series of new compounds containing 2-pyrrolidinomethyl and 2-piperazinomethyl groups and 2-morpholino and 2-morpholinoethylamine substituents were synthesized. The antiglycation activities of 2-(morpholin-4-yl)-1-(propen-2-en-1-yl)-1H-benzimidazole and 2-(morpholin-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole were comparable to that of aminoguanidine. Some compounds exhibited moderate antiserotonin, anti-angiotensin, antioxidant, and dipeptidyl peptidase-4 (DPP-4) inhibitory effects.
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页码：201 / 206
页数：5
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