This prospective study tested the diathesis-stress and symptom components of the integration of the hopelessness and self-esteem theories of depression in a sample of third- and seventh-grade children. The procedure involved an initial assessment of depressive symptoms, self-esteem, and depressogenic inferential styles about causes, consequences, and the self. The procedure also involved a follow-up assessment, 6 weeks later, in which depressive symptoms and the occurrence of negative events were assessed. In line with the integrative theory, depressogenic inferential styles interacted with negative events to predict increases in hopelessness but not nonhopelessness depression symptoms in boys with low but not high self-esteem. At the same time, contrary to the integrative theory, depressogenic inferential styles interacted with negative events to predict increases in hopelessness but not nonhopelessness depression symptoms in girls with high but not low self-esteem.