Anti-oligosaccharide antibodies as tools for studying sulfated sialoglycoconjugate ligands for siglecs and selectins

被引：0
|
作者：
Reiji Kannagi
Katsuyuki Ohmori
Naoko Kimura
机构：
[1] Aichi Cancer Center,Department of Molecular Pathology, Research Institute
[2] Kyoto University,Department of Clinical Pathology, School of Medicine
来源：
Glycoconjugate Journal | 2009年 / 26卷
关键词：
Selectin; Siglec; CD22; Skin-homing helper memory T-lymphocytes; Cutaneous lymphocyte antigen; Naïve B-lymphocytes;
D O I：
暂无
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学科分类号：
摘要：
Several sulfated sialoglycoconjugates have recently been shown to serve as ligands for selectins and siglecs. For instance, α2→3 sialylated 6-sulfo-Lewis x was found to serve as a ligand for selectins on skin-homing helper memory T cells, and α2→6 sialylated 6-sulfo-LacNAc to be a preferred ligand for CD22/siglec-2 on human naïve B cells. Monoclonal antibodies specific to sulfated sialoglycoconjugates are effective tools to dissect these ligands on minor subsets of human leukocytes.
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页码：923 / 928
页数：5
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