Models of traumatic brain injury

被引:3
|
作者
Laurer H.L. [1 ,2 ]
Lenzlinger P.M. [1 ]
McIntosh T.K. [1 ]
机构
[1] Department of Neurosurgery, University of Pennsylvania Medical School, Philadelphia, PA
[2] Department of Trauma Surgery, Saarland University Medical School, Homburg/Saar
来源
European Journal of Trauma | 2000年 / 26卷 / 3期
关键词
Experimental models; Rodent; Traumatic brain injury;
D O I
10.1007/s000680050007
中图分类号
学科分类号
摘要
We present a review of the currently popular preclinical models of non- penetrating traumatic brain injury (TBI). This article focuses on animal models that cause TBI by applying mechanical energy to the head, skull or dura. It attempts to provide a compendium of the main characteristics of each of these experimental models of TBI in respect to acute and chronic histological findings and behavioral impairment in neurologic motor and cognitive function. Finally, several limitations of the described models are discussed briefly.
引用
收藏
页码:95 / 110
页数:15
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