Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

被引：0

作者：

Gavin M Bendle

Carsten Linnemann

Anna I Hooijkaas

Laura Bies

Moniek A de Witte

Annelies Jorritsma

Andrew D M Kaiser

Nadine Pouw

Reno Debets

Elisa Kieback

Wolfgang Uckert

Ji-Ying Song

John B A G Haanen

Ton N M Schumacher

机构：

[1] The Netherlands Cancer Institute,Division of Immunology

[2] Laboratory of Experimental Tumor Immunology,Department of Medical Oncology

[3] Erasmus MC-Daniel den Hoed Cancer Center,Division of Experimental Animal Pathology

[4] Max Delbrück Center for Molecular Medicine,Division of Medical Oncology

[5] The Netherlands Cancer Institute,undefined

[6] The Netherlands Cancer Institute,undefined

来源：

Nature Medicine | 2010年 / 16卷

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摘要：

T cell receptor (TCR) gene therapy is a promising immunotherapy for cancer and infectious disease. But introducing exogenous TCR α and β chains into T cells may have unintended consequences. In this issue, Bendle et al. show that the transfer of TCR-transduced T cells into mice triggered a lethal pathology that resembles graft-versus-host disease and is caused by the pairing of endogenous and exogenous TCR chains resulting in autoreactive T cells (pages 520–521).

引用

页码：565 / 570

页数：5

共 50 条

[1] Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
Bendle, Gavin M.
Linnemann, Carsten
Hooijkaas, Anna I.
Bies, Laura
de Witte, Moniek A.
Jorritsma, Annelies
Kaiser, Andrew D. M.
Pouw, Nadine
Debets, Reno
Kieback, Elisa
Uckert, Wolfgang
Song, Ji-Ying
Haanen, John B. A. G.
Schumacher, Ton N. M.
NATURE MEDICINE, 2010, 16 (05) : 565 - U98
[2] Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
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de Witte, M.
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