Use of Clozapine in a State Child and Adolescent Psychiatric Hospital

被引:0
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作者
Vanessa Bobb
Michael Weinberg
Stewart Gabel
Harvey Kranzler
Mark Olfson
机构
[1] New York State Office of Mental Health,New York City Children’s Center
[2] Columbia University,Department of Psychiatry, New York State Psychiatric Institute
[3] Upstate Medical University,Department of Psychiatry, State University of New York
[4] Albert Einstein College of Medicine,Department of Psychiatry
来源
Psychiatric Quarterly | 2013年 / 84卷
关键词
Clozapine; Youth; Pharmacology; Aggression; Inpatient;
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摘要
We assessed the predictors of clozapine initiation among youth 18 years and younger within a state psychiatric hospital. Administrative data (n = 358) were evaluated of inpatients from a long-term state child and adolescent psychiatric hospital. We investigated 25 background and clinical patient characteristics to determine which factors predicted clozapine initiation following the first 21 days of hospital admission. A Cox proportional model was used to evaluate factors that independently predicted the hazard rate of clozapine initiation. Emergency medication administration during the first 3 weeks of admission, which was more common among the clozapine (84.9 %) than control (61.7 %) patients (p < 0.001), was associated with a significantly increased probability of clozapine initiation (Hazard Ratio = 1.9, 95 % Confidence Interval = 1.2–3.1). Use of a mood stabilizer during the first 3 weeks of the inpatient was non-significantly related to an increased probability of clozapine initiation (Hazard Ratio = 1.7, 95 % Confidence Interval = 1.0–2.9). In this setting, emergency medication use predicts clozapine initiation suggesting that it may be used to treat patients with aggressive behavior.
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页码:343 / 349
页数:6
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