Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial

被引:0
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作者
R Kaaks
C Bellati
E Venturelli
S Rinaldi
G Secreto
C Biessy
V Pala
S Sieri
F Berrino
机构
[1] Hormones and Cancer Group,
[2] International Agency for Research on Cancer,undefined
[3] Unit of Epidemiology Istituto Nazionale dei Tumori,undefined
[4] Unit of Nuclear Medicine,undefined
[5] Istituto Nazionale dei Tumori,undefined
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关键词
diet; growth hormone; estradiol; intervention study; growth hormone-binding protein; sex hormone-binding globulin;
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摘要
Objective: To assess the effects of a comprehensive change in dietary composition on endogenous hormone metabolism. The specific aim was to examine whether this intervention could lead to favourable changes in insulin sensitivity, levels of IGF-I and IGF-binding proteins (IGFBPs), and total and bioavailable testosterone and estradiol, that would be expected to reduce breast cancer risk.
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页码:1079 / 1088
页数:9
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