Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs

被引：0

作者：

Nicolette H C Salmon Hillbertz

Magnus Isaksson

Elinor K Karlsson

Eva Hellmén

Gerli Rosengren Pielberg

Peter Savolainen

Claire M Wade

Henrik von Euler

Ulla Gustafson

Åke Hedhammar

Mats Nilsson

Kerstin Lindblad-Toh

Leif Andersson

Göran Andersson

机构：

[1] Swedish University of Agricultural Sciences (SLU),Department of Animal Breeding and Genetics

[2] Biomedical Centre,Department of Genetics and Pathology

[3] Box 597,Department of Anatomy

[4] The Rudbeck Laboratory,Department of Medical Biochemistry and Microbiology

[5] Uppsala University,Department of Clinical Sciences

[6] Broad Institute of Harvard and MIT,undefined

[7] 7 Cambridge Center,undefined

[8] Bioinformatics Program,undefined

[9] Boston University,undefined

[10] Physiology and Biochemistry,undefined

[11] SLU,undefined

[12] Box 7011,undefined

[13] Uppsala University,undefined

[14] Box 597,undefined

[15] School of Biotechnology,undefined

[16] Royal Institute of Technology,undefined

[17] AlbaNova University Center,undefined

[18] Center for Human Genetic Research,undefined

[19] Massachusetts General Hospital,undefined

[20] SLU,undefined

[21] Box 7054,undefined

来源：

Nature Genetics | 2007年 / 39卷

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摘要：

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.

引用

页码：1318 / 1320

页数：2

共 9 条

[1] Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs
Hillbertz, Nicolette H. C. Salmon
Isaksson, Magnus
Karlsson, Elinor K.
Hellmen, Eva
Pielberg, Gerli Rosengren
Savolainen, Peter
Wade, Claire M.
Von Euler, Henrik
Gustafson, Ulla
Hedhammar, Ake
Nilsson, Mats
Lindblad-Toh, Kerstin
Andersson, Leif
Andersson, Goran
NATURE GENETICS, 2007, 39 (11) : 1318 - 1320
[2] PRECISION THERAPY IN HEPATOCELLULAR CARCINOMA: ASSOCIATION OF FGF3, FGF4, AND FGF19 AMPLIFICATION WITH RESPONSE TO SORAFENIB
Hassan, Hind
Ali, Mohamed Abdulwahab Mohamed
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Hassan, Fatma
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Goodwin, Leslie O.
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Donahue, Leah Rae
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MAMMALIAN GENOME, 2023, 34 (03) : 453 - 463
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Sarah Edie
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Rachel Urban
Leslie O. Goodwin
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Bertola, Debora R.
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AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2007, 143A (16) : 1912 - 1918
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FRONTIERS IN PHARMACOLOGY, 2022, 13

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