A high-throughput in vivo micronucleus assay for genome instability screening in mice

被引：0
|
作者：
Gabriel Balmus
Natasha A Karp
Bee Ling Ng
Stephen P Jackson
David J Adams
Rebecca E McIntyre
机构：
[1] The Wellcome Trust/Cancer Research UK Gurdon Institute,
[2] University of Cambridge,undefined
[3] Maintenance of Genome Stability,undefined
[4] The Wellcome Trust Sanger Institute,undefined
[5] Genome Campus,undefined
[6] The Sanger Mouse Genetics Project,undefined
[7] The Wellcome Trust Sanger Institute,undefined
[8] Genome Campus,undefined
[9] Cytometry Core Facility,undefined
[10] The Wellcome Trust Sanger Institute,undefined
[11] Genome Campus,undefined
[12] Experimental Cancer Genetics,undefined
[13] The Wellcome Trust Sanger Institute,undefined
[14] Genome Campus,undefined
来源：
Nature Protocols | 2015年 / 10卷
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学科分类号：
摘要：
This protocol describes a sensitive, robust, high-throughput method for quantifying the formation of micronuclei in mouse erythrocytes. It detects low levels of genome instability and can be used to identify novel genome maintenance genes and models.
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页码：205 / 215
页数：10
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