Non-canonical RNA-directed DNA methylation

被引：0
|
作者：
Cuerda-Gil D. [1 ]
Slotkin R.K. [1 ,2 ]
机构：
[1] Department of Molecular Genetics, Ohio State University, 500 Aronoff Laboratory, Columbus, 43210, OH
[2] Center for RNA Biology, Ohio State University, 484 West Twelfth Avenue, Columbus, 43210, OH
来源：
Nature Plants | / 2卷 / 11期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1038/nplants.2016.163
中图分类号：
学科分类号：
摘要：
Small RNA-directed DNA methylation (RdDM) has been extensively studied in plants, resulting in a deep understanding of a major âcanonical RdDM' mechanism. However, current models of canonical RdDM cannot explain how this self-perpetuating mechanism is initiated. Recent investigations into the initiation of epigenetic silencing have determined that there are several alternative â non-canonical RdDM' pathways that function through distinct mechanisms to modify chromatin. This Review aims to illustrate the diversity of non-canonical RdDM mechanisms described to date, recognize common themes within this dizzying array of interconnected pathways, and identify the key unanswered questions remaining in this field. © 2016 Macmillan Publishers Limited. All rights reserved.
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