Synthesis, characterization and enantioselectivity of cholic acid-bonded phases for high performance liquid chromatography

被引：0
|
作者：
L. Vaton-Chanvrier
V. Peulon
Y. Combret
J. C. Combret
机构：
[1] Université de Rouen,IRCOF, Laboratoire d’Hétérochimie Organique, Faculté des Sciences et Techniques
来源：
Chromatographia | 1997年 / 46卷
关键词：
Column liquid chromatography; New bonded stationary phases; Enantiomer separation; Cholic acid derivatives;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two cholic acid derivatives have been synthesized and bonded to porous silica via a hydride-modified substrate. The supports obtained, which were characterized by differential scanning calorimetric and infrared measurements, were found to be enantioselective for a variety of analytes in normal-phase high-performance liquid chromatography. Optimization of enantiomer separations was achieved by studying the influence of mobile phase composition. The effect of substituents on the retention and resolution of hydantoins and naphthylethyl-amines has been evaluated. General considerations of the separation mechanism on both stationary phases are discussed.
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页码：613 / 622
页数：9
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