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- [2] Is Intention to Treat Still the Gold Standard or Should Health Technology Assessment Agencies Embrace a Broader Estimands Framework? Insights and Perspectives From the National Institute for Health and Care Excellence and Institut f?r Qualit?t und Wirtschaftlichkeit im Gesundheitswesen on the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use E9 (R1) Addendum VALUE IN HEALTH, 2023, 26 (02) : 234 - 242