Immunological properties of attenuated variants of African swine fever virus isolated in the Russian Federation

被引：3
|
作者：
V. I. Balysheva
E. Yu. Prudnikova
T. V. Galnbek
V. M. Balyshev
机构：
[1] All-Russian Veterinary Virology and Microbiology Research Institute,
[2] All-Russian Experimental Veterinary Research Institute,undefined
来源：
Russian Agricultural Sciences | 2015年 / 41卷 / 2-3期
关键词：
African Swine Fever Virus; adaptation; continuous cell lines; immunobiological characteristics; hemadsorption;
D O I：
10.3103/S1068367415020056
中图分类号：
学科分类号：
摘要：
The paper presents the results of adaptation of the African swine fever (ASF) virus strain Stavropol to continuous cell cultures of homologous (A4C2, A4C2/9k, PSGK-60, and PPK-66b) and heterologous (CV-1) origin in which the virus accumulated at titers of respectively 5.0–6.5 and 4.0–4.5 logHAU50/cm3. In this case, the African swine fever virus (ASFV) multiplied in the A4C2 and A4C2/9k cell cultures with manifestation of specific hemadsorption with pig erythrocytes. The ASFV culture variants of passages 24 and 33 in the A4C2/9k and passage 20 in the CV-1 cell cultures lost pathogenicity for pigs but didn’t protect them from death after challenged with a virulent virus.
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页码：178 / 182
页数：4
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