Pancreatic β-cell mRNA modification as a marker for type 2 diabetes

被引：0
|
作者：
Erik Renström
Enming Zhang
机构：
[1] Lund University,Lund University Diabetes Centre, Exodiab Strategic Research Area in Diabetes, Department of Clinical Sciences Malmö
来源：
Nature Metabolism | 2019年 / 1卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Diabetes mellitus invariably involves impaired regulation of insulin secretion from pancreatic β cells, as a result of unfavourable environmental influences in combination with aberrant expression of risk genes at either the transcriptional or the translational level. A recent report in Nature Metabolism explores a novel role of mRNA methylation in β-cell function and suggests that its downregulation causes type 2 diabetes.
引用
收藏
页码：748 / 749
页数：1
相关论文
共 50 条
  • [1] DIABETES Pancreatic β-cell mRNA modification as a marker for type 2 diabetes
    Renstrom, Erik
    Zhang, Enming
    NATURE METABOLISM, 2019, 1 (08) : 748 - 749
  • [2] Type 2 Diabetes and the Aging Pancreatic Beta Cell
    Gunasekaran, Uma
    Gannon, Maureen
    AGING-US, 2011, 3 (06): : 565 - 575
  • [3] Investigation of the Effect of Canagliflozin on the Disposition Index, a Marker of Pancreatic Beta Cell Function, in Patients with Type 2 Diabetes
    Takahara, Mitsuyoshi
    Shiraiwa, Toshihiko
    Matsuoka, Taka-aki
    Yamamoto, Kaoru
    Maeno, Yoshifumi
    Shiraiwa, Yuka
    Yoshida, Yoko
    Katakami, Naoto
    Iijima, Hiroaki
    Katsumata, Hideyuki
    Arakawa, Kenji
    Hashimoto, Toshio
    Shimomura, Iichiro
    DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2020, 13 : 4457 - 4468
  • [4] Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
    Jinsook Son
    Domenico Accili
    Experimental & Molecular Medicine, 2023, 55 : 1652 - 1658
  • [5] Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
    Son, Jinsook
    Accili, Domenico
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2023, 55 (08): : 1652 - 1658
  • [6] Pancreatic Beta-cell Dysfunction in Type 2 Diabetes
    Khin, Phyu Phyu
    Lee, Jong Han
    Jun, Hee-Sook
    EUROPEAN JOURNAL OF INFLAMMATION, 2023, 21
  • [7] RAGE Contributes to Pancreatic β-Cell Failure in Type 2 Diabetes
    Han, Dong
    Yamamoto, Yasuhiko
    Tsuneyama, Koichi
    Munesue, Seiichi
    Yamamoto, Hiroshi
    DIABETES, 2012, 61 : A522 - A522
  • [8] Roles of autophagy in pancreatic β-cell function and type 2 diabetes
    Fujitani Y.
    Uchida T.
    Komiya K.
    Abe H.
    Kawamori R.
    Watada H.
    Diabetology International, 2011, 2 (1) : 1 - 9
  • [9] Pancreatic β-cell mass in European subjects with type 2 diabetes
    Rahier, J.
    Guiot, Y.
    Goebbels, R. M.
    Sempoux, C.
    Henquin, J. C.
    DIABETES OBESITY & METABOLISM, 2008, 10 : 32 - 42
  • [10] Pancreatic β-cell defects in women at risk of type 2 diabetes
    Pimenta, WP
    Rudge, MVC
    Aragon, FF
    Padovani, CR
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2004, 63 (02) : 87 - 92
12345