KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases

被引：0
|
作者：
S. Fukaya
H. Oshima
K. Kato
Y. Komatsu
H. Matsumura
K. Ishii
H. Miyama
T. Nagai
I. Tanaka
A. Mizutani
M. Katayama
S. Yoshida
K. Torikai
机构：
[1] Department of Medicine,
[2] Fujita Health University School of Medicine,undefined
[3] Toyoake,undefined
[4] Aichi 470-1192,undefined
[5] Japan e-mail: hoshima@fujita-hu.ac.jp Tel.: +81-562-93-9244; Fax: +81-562-95-0081,undefined
来源：
Rheumatology International | 2000年 / 19卷
关键词：
Key words Interstitial pneumonia; KL-6; Corticosteroids; Marker;
D O I：
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中图分类号：
学科分类号：
摘要：
The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.
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页码：223 / 225
页数：2
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