NMDA Receptors Regulate Genes Responsible for Major Immune Functions of Mononuclears in Human Peripheral Blood

被引：0
|
作者：
U. Sh. Kuzmina
L. F. Zainullina
S. V. Sadovnikov
V. A. Vakhitov
Yu. V. Vakhitova
机构：
[1] Russian Academy of Sciences,Institute of Biochemistry and Genetics, Ufa Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 165卷
关键词：
NMDA receptors; transcriptome analysis; peripheral blood mononuclears; (+)-MK-801;
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学科分类号：
摘要：
To determine the role of NMDA receptors in the functional regulation of immunocompetent cells, comparative assay was carried out for genes expressed in the mononuclears in peripheral blood of healthy persons under normal conditions and after blockade of these receptors. The genes, whose expression changed in response to blockade of NMDA receptors in mononuclears, encode the products involved in regulation of the major functions of immune cells, such as proliferation (IL4, VCAM1, and CDKN2A), apoptosis (BAX, MYC, CDKN2A, HSPB1, and CADD45A), activation (IL4R, IL4, VCAM1, and CDKN2A), and differentiation (IL4, VCAM1, and BAX).
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页码：252 / 255
页数：3
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