In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

被引：0

作者：

Yasushi Itoh

Kyoko Shinya

Maki Kiso

Tokiko Watanabe

Yoshihiro Sakoda

Masato Hatta

Yukiko Muramoto

Daisuke Tamura

Yuko Sakai-Tagawa

Takeshi Noda

Saori Sakabe

Masaki Imai

Yasuko Hatta

Shinji Watanabe

Chengjun Li

Shinya Yamada

Ken Fujii

Shin Murakami

Hirotaka Imai

Satoshi Kakugawa

Mutsumi Ito

Ryo Takano

Kiyoko Iwatsuki-Horimoto

Masayuki Shimojima

Taisuke Horimoto

Hideo Goto

Kei Takahashi

Akiko Makino

Hirohito Ishigaki

Misako Nakayama

Masatoshi Okamatsu

Kazuo Takahashi

David Warshauer

Peter A. Shult

Reiko Saito

Hiroshi Suzuki

Yousuke Furuta

Makoto Yamashita

Keiko Mitamura

Kunio Nakano

Morio Nakamura

Rebecca Brockman-Schneider

Hiroshi Mitamura

Masahiko Yamazaki

Norio Sugaya

M. Suresh

Makoto Ozawa

Gabriele Neumann

James Gern

Hiroshi Kida

机构：

[1] Shiga University of Medical Science,Department of Pathology

[2] Ohtsu,Department of Microbiology and Infectious Diseases

[3] Shiga 520-2192,Division of Virology, Department of Microbiology and Immunology

[4] Japan,Department of Pathobiological Sciences

[5] Kobe University,Department of Disease Control

[6] Institute of Medical Science,Department of Special Pathogens

[7] University of Tokyo,Department of Infectious Diseases

[8] University of Wisconsin-Madison,Department of Public Health

[9] Madison,Department of Internal Medicine

[10] Wisconsin 53711,Department of Pediatrics

[11] USA,undefined

[12] Graduate School of Veterinary Medicine,undefined

[13] Hokkaido University,undefined

[14] ERATO Infection-Induced Host Responses Project,undefined

[15] International Research Center for Infectious Diseases,undefined

[16] Institute of Medical Science,undefined

[17] University of Tokyo,undefined

[18] Osaka Prefectural Institute of Public Health,undefined

[19] Wisconsin State Laboratory of Hygiene,undefined

[20] Madison,undefined

[21] Wisconsin 53706,undefined

[22] USA ,undefined

[23] Niigata University,undefined

[24] Graduate School of Medical and Dental Sciences,undefined

[25] Toyama Chemical Co.,undefined

[26] Ltd.,undefined

[27] Daiichi Sankyo Co Ltd,undefined

[28] Shinagawa,undefined

[29] Tokyo 140–8710,undefined

[30] Japan ,undefined

[31] Eiju General Hospital,undefined

[32] School of Medicine and Public Health,undefined

[33] University of Wisconsin-Madison,undefined

[34] Madison,undefined

[35] Wisconsin 53792,undefined

[36] USA ,undefined

[37] Mitamura Clinic,undefined

[38] Zama Children’s Clinic,undefined

[39] Keiyu Hospital,undefined

[40] Creative Research Initiative,undefined

[41] Sousei,undefined

[42] Hokkaido University,undefined

来源：

Nature | 2009年 / 460卷

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摘要：

Analysis of a series of clinical isolates of the swine-origin H1N1 influenza virus reveals that in mammalian models (mice, ferrets and macaques) the current pandemic virus is associated with more severe disease than a seasonal H1N1 strain. The viruses can also infect pigs but do not cause clinical signs. All antivirus drugs tested, including Tamiflu, were effective in cell culture against the new virus, lending support to the use of these compounds as a first line of defence against the pandemic.

引用

页码：1021 / 1025

页数：4

共 50 条

[1] In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Itoh, Yasushi
Shinya, Kyoko
Kiso, Maki
Watanabe, Tokiko
Sakoda, Yoshihiro
Hatta, Masato
Muramoto, Yukiko
Tamura, Daisuke
Sakai-Tagawa, Yuko
Noda, Takeshi
Sakabe, Saori
Imai, Masaki
Hatta, Yasuko
Watanabe, Shinji
Li, Chengjun
Yamada, Shinya
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Warshauer, David
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Brockman-Schneider, Rebecca
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Ozawa, Makoto
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