Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

被引：0

作者：

Liz Rietschel

Fabian Streit

Gu Zhu

Kerrie McAloney

Josef Frank

Baptiste Couvy-Duchesne

Stephanie H. Witt

Tina M. Binz

John McGrath

Ian B. Hickie

Narelle K. Hansell

Margaret J. Wright

Nathan A. Gillespie

Andreas J. Forstner

Thomas G Schulze

Stefan Wüst

Markus M. Nöthen

Markus R. Baumgartner

Brian R. Walker

Andrew A. Crawford

Lucía Colodro-Conde

Sarah E. Medland

Nicholas G. Martin

Marcella Rietschel

机构：

[1] University Hospital of Child and Adolescent Psychiatry and Psychotherapy,Department of Genetics

[2] Research Department,Department of Psychiatry

[3] University of Bern,undefined

[4] SRH University Heidelberg,undefined

[5] Academy for Psychotherapy,undefined

[6] Department of Genetic Epidemiology in Psychiatry,undefined

[7] Central Institute of Mental Health,undefined

[8] Medical Faculty Mannheim,undefined

[9] University of Heidelberg,undefined

[10] Genetics & Computational Biology Department,undefined

[11] QIMR Berghofer Medical Research,undefined

[12] Queensland Brain Institute,undefined

[13] University of Queensland,undefined

[14] Zurich Institute of Forensic Medicine,undefined

[15] Centre for Forensic Hair Analysis,undefined

[16] University of Zurich,undefined

[17] Queensland Centre for Mental Health Research,undefined

[18] The Park Centre for Mental Health,undefined

[19] National Centre for Register-Based Research,undefined

[20] Aarhus University,undefined

[21] Brain and Mind Centre,undefined

[22] University of Sydney,undefined

[23] Centre for Advanced Imaging,undefined

[24] University of Queensland,undefined

[25] Virginia Institute for Psychiatric and Behavioral Genetics,undefined

[26] Virginia Commonwealth University,undefined

[27] Richmond,undefined

[28] Institute of Human Genetics,undefined

[29] University of Bonn,undefined

[30] Life & Brain Center,undefined

[31] Department of Genomics,undefined

[32] University of Bonn,undefined

[33] Department of Psychiatry (UPK),undefined

[34] University of Basel,undefined

[35] Human Genomics Research Group,undefined

[36] Department of Biomedicine,undefined

[37] University of Basel,undefined

[38] Department of Psychiatry and Behavioral Sciences,undefined

[39] Johns Hopkins University,undefined

[40] Institute of Psychiatric Phenomics and Genomics (IPPG),undefined

[41] Medical Center of the University of Munich,undefined

[42] Campus Innenstadt,undefined

[43] Human Genetics Branch,undefined

[44] NIMH Division of Intramural Research Programs,undefined

[45] Department of Psychiatry and Psychotherapy,undefined

[46] University Medical Center Göttingen,undefined

[47] Institute of Experimental Psychology,undefined

[48] University of Regensburg,undefined

[49] British Heart Foundation Centre for Cardiovascular Science,undefined

[50] Queen’s Medical Research Institute,undefined

来源：

Scientific Reports | / 7卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.

引用

共 39 条

[1] Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes
Rietschel, Liz
Streit, Fabian
Zhu, Gu
McAloney, Kerrie
Frank, Josef
Couvy-Duchesne, Baptiste
Witt, Stephanie H.
Binz, Tina M.
McGrath, John
Hickie, Ian B.
Hansell, Narelle K.
Wright, Margaret J.
Gillespie, Nathan A.
Forstner, Andreas J.
Schulze, Thomas G.
Wust, Stefan
Nothen, Markus M.
Baumgartner, Markus R.
Walker, Brian R.
Crawford, Andrew A.
Colodro-Conde, Lucia
Medland, Sarah E.
Martin, Nicholas G.
Rietschel, Marcella
[J]. SCIENTIFIC REPORTS, 2017, 7
[2] HERITABILITY OF HAIR CORTISOL AND GENETIC OVERLAP WITH PSYCHOLOGICAL VARIABLES
Streit, Fabian
Rietschel, Liz
Zhu, Gu
McAloney, Kerrie
Binz, Tina
Hansell, Narelle K.
Wright, Margie
Gillespie, Nathan
Noethen, Markus
Baumgartner, Markus
Conde, Lucia Colodro
Martin, Nick
Rietschel, Marcella
[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2019, 29 : S913 - S913
[3] Heritability of hair cortisol and genetic overlap with psychological variables
Streit, Fabian
Rietschel, Liz
Zhu, Gu
McAloney, Kerrie
Frank, Josef
Couvy-Duchesne, Baptiste
Witt, Stephanie H.
Binz, Tina
McGrath, John
Hickie, Ian B.
Hansell, Narelle K.
Wright, Margaret J.
Gillespie, Nathan
Forstner, Andreas J.
Schulze, Thomas G.
Wuest, Stefan
Noethen, Markus M.
Baumgartner, Markus
Walker, Brian R.
Crawford, Andrew A.
Conde, Lucia Colodro
Medland, Sarah E.
Martin, Nicholas G.
Rietschel, Marcella
[J]. PSYCHONEUROENDOCRINOLOGY, 2017, 83 : 80 - 80
[4] Stress-System Genes and Life Stress Predict Cortisol Levels and Amygdala and Hippocampal Volumes in Children
David Pagliaccio
Joan L Luby
Ryan Bogdan
Arpana Agrawal
Michael S Gaffrey
Andrew C Belden
Kelly N Botteron
Michael P Harms
Deanna M Barch
[J]. Neuropsychopharmacology, 2014, 39 : 1245 - 1253
[5] Stress-System Genes and Life Stress Predict Cortisol Levels and Amygdala and Hippocampal Volumes in Children
Pagliaccio, David
Luby, Joan L.
Bogdan, Ryan
Agrawal, Arpana
Gaffrey, Michael S.
Belden, Andrew C.
Botteron, Kelly N.
Harms, Michael P.
Barch, Deanna M.
[J]. NEUROPSYCHOPHARMACOLOGY, 2014, 39 (05) : 1245 - 1253
[6] Heritability and genetic correlation of hair cortisol in vervet monkeys in low and higher stress environments
Fairbanks, Lynn A.
Jorgensen, Matthew J.
Bailey, Julia N.
Breidenthal, Sherry E.
Grzywa, Rachel
Laudenslager, Mark L.
[J]. PSYCHONEUROENDOCRINOLOGY, 2011, 36 (08) : 1201 - 1208
[7] Psychological and Sociodemographic Variables related to Cortisol in Hair in Spanish Healthy Population
Arco Garcia, Laura
Gonzalez Perez, Raquel
Henares Extremera, Alejandra
Garcia Leon, Maria Angeles
Isabel Peralta-Ramirez, Maria
[J]. SPANISH JOURNAL OF PSYCHOLOGY, 2020, 23
[8] Heritability of basic psychological needs and their overlap with personality traits on the phenotypic, genetic, and environmental level
Bratko, D.
Butkovic, A.
Hlupic, Vukasovic T.
Pocrnic, M.
[J]. PERSONALITY AND INDIVIDUAL DIFFERENCES, 2024, 221
[9] Hair cortisol and its Association with Symptoms of Depression, Neuroticism and Perceived Stress in Adolescent Twins
Rietschel, Liz
Streit, Fabian
Zhu, Gu
McAloney, Kerrie
Kirschbaum, Clemens
Hansell, Narelle K.
Wright, Margie
McGrath, John J.
Witt, Stephanie
Rietschel, Marcella
Martin, Nicholas G.
[J]. EARLY INTERVENTION IN PSYCHIATRY, 2016, 10 : 217 - 217
[10] STRESS RESPONSE GENES AND HAIR CORTISOL LEVELS IN FIRST NATION COMMUNITIES
Zai, Clement
George, Julie
Irwin, David
Shaikh, Sajid
Tampakeras, Maria
Sibony, David
Danesi, Michael
Freeman, Natalie
Russell, Evan
Rehm, Jurgen
van Uum, Stan
Koren, Gideon
Graham, Kathryn
Wells, Samantha
Kennedy, James
[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2017, 27 : S320 - S320

← 1 2 3 4 →