Expert consensus on clinical applications of high-frequency oscillations in epilepsy

被引:0
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作者
Yuping Wang
Dong Zhou
Xiaofeng Yang
Xin Xu
Liankun Ren
Tao Yu
Wenjing Zhou
Xiaoqiu Shao
Zhixian Yang
Shuang Wang
Dezhi Cao
Chunyan Liu
Shang Yeong Kwan
Jing Xiang
机构
[1] Xuanwu Hospital,Department of Neurology
[2] Capital Medical University,Center of Epilepsy
[3] Beijing Key Laboratory of Neuromodulation,Department of Neurology
[4] Beijing Institute of Brain Disorders,Neuroelectrophysiological Laboratory
[5] Capital Medical University,Department of Neurosurgery
[6] West China Hospital,Department of Functional Neurosurgery
[7] Sichuan University,Epilepsy Center
[8] Xuanwu Hospital,Department of Neurology
[9] Capital Medical University,Department of Pediatrics
[10] General Hospital of PLA,Epilepsy Center
[11] Xuanwu Hospital,Department of Neurology
[12] Capital Medical University,Section of Epilepsy
[13] Tsinghua University Yuquan Hospital,MEG Center
[14] Beijing Tiantan Hospital,Division of Neurology
[15] Capital Medical University,undefined
[16] China National Clinical Research Center for Neurological Disease NCRC-ND,undefined
[17] Peking University First Hospital,undefined
[18] Second Affiliated Hospital,undefined
[19] School of Medicine,undefined
[20] Zhejiang University,undefined
[21] Shenzhen Children’s Hospital,undefined
[22] Neurological Institute,undefined
[23] Taipei Veterans General Hospital,undefined
[24] Cincinnati Children’s Hospital Medical Center,undefined
[25] Cincinnati Children’s Hospital Medical Center,undefined
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关键词
High-frequency oscillations; Ripple; Fast ripple; Interictal spike; Epilepsy; Biomarker;
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摘要
Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations (HFOs, > 80 Hz) and the epileptogenic zone, suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis. This consensus includes the definition and standard detection techniques of HFOs, the localizing value of pathological HFOs for epileptic foci, and different ways to distinguish physiological from epileptic HFOs. The latest clinical applications of HFOs in epilepsy and the related findings are also discussed. HFOs will advance our understanding of the pathophysiology of epilepsy.
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