Localized targeted antiangiogenic drug delivery for glioblastoma

被引：0
|
作者：
Gregory D. Arnone
Abhiraj D. Bhimani
Tania Aguilar
Ankit I. Mehta
机构：
[1] University of Illinois at Chicago,Department of Neurosurgery
来源：
Journal of Neuro-Oncology | 2018年 / 137卷
关键词：
Glioblastoma; Glioma; VEGF; Angiogenesis; Local drug delivery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Systemic delivery of antiangiogenic agents has been ineffective in improving the overall survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting toxicities. With the development of new and efficient localized delivery methods and vehicles, an otherwise lethal dose of antiangiogenic chemotherapy can be used to treat tumors while minimizing systemic side effects. Current in-vitro and in-vivo animal studies have shown promising results that encourage the pursuit towards human clinical trials for localized antiangiogenic treatment in the near future.
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页码：223 / 231
页数：8
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