Effect of NO Synthase Inhibitor L-NAME on DNA Synthesis in the Myocardium of Albino Rats during Early Postnatal Ontogeny

被引：0
|
作者：
E. N. Sazonova
V. M. Pikalova
S. S. Timoshin
机构：
[1] Far-Eastern State Medical University,Central Research Laboratory
来源：
Bulletin of Experimental Biology and Medicine | 2002年 / 133卷
关键词：
nitric oxide synthase; DNA synthesis; myocardium; lipid peroxidation;
D O I：
暂无
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学科分类号：
摘要：
Effects of repeated treatment (5 times) with L-NAME, a NO synthase (eNOS) inhibitor on DNA synthesis in various zones of the heart in newborn albino rats was studied using 3H-thymidine autoradiography. This compound decreased (by 1.22-1.59 times) the count of labeled cardiomyocyte nuclei in various myocardial zones, particularly, in the myocardium of the left atrium, left ventricle, and interventricular septum. Changes in tissue proliferative activity were accompanied by activation of lipid peroxidation and inhibition of the antioxidant system in the myocardium.
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页码：20 / 22
页数：2
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