Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone

被引：0
|
作者：
Magdalena Kościelniak-Ziemniak
Barbara Pilawa
机构：
[1] Medical University of Silesia in Katowice,Department of Biophysics, School of Pharmacy and Laboratory Medicine
[2] The Zbigniew Religa Foundation of Cardiac Surgery Development,Artificial Heart Laboratory
来源：
Applied Magnetic Resonance | 2013年 / 44卷
关键词：
Electron Paramagnetic Resonance; Electron Paramagnetic Resonance Spectrum; Microwave Power; Paramagnetic Center; Electron Paramagnetic Resonance Spectroscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Thermal formation of free radicals in flumetasone sterilized according to the pharmaceutical norms at 160, 170 and 180 °C was examined by electron paramagnetic resonance (EPR) spectroscopy. The microbiological analysis was done. Similar free radical concentrations were measured for flumetasone sterilized at 160 and 170 °C. The concentration was considerably higher than that for flumetasone sterilized at 180 °C. Fast spin–lattice relaxation processes, homogeneously broadened EPR lines, and complex free radicals system characterize the heated flumetasone. Free radicals were not observed 30 days after thermal sterilization. Optimal temperatures of sterilization of flumetasone are 160 and 170 °C.
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页码：1431 / 1443
页数：12
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