Clinical Evaluation of the Analgesic Effect of Sustained Release Morphine Sulfate Microgranules in Patients with Terminal Cancer

被引：0
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作者：
Guo-Zhu Xu
Zhi-Ji Cai
Yan-Ping Deng
Jun Hou
Guang-Ru Xie
Shu-Jun Liu
机构：
[1] Beijing Medical University,National Institute on Drug Dependence
[2] Hebei Cancer Institute,College of Oncology
[3] Tianjin Cancer Hospital,undefined
[4] Beijing Medical University,undefined
来源：
Clinical Drug Investigation | 1997年 / 14卷
关键词：
Adis International Limited; Pain Relief; Sustained Release; Numerical Rating Scale; Drug Invest;
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摘要：
A randomised controlled clinical trial evaluating the analgesic effect of capsules containing sustained release (SR) morphine sulfate microgranules (M-Eslon®) was conducted in 120 patients with terminal cancer and moderate or severe pain. SR morphine sulfate as a tablet formulation (MS-Contin®) was used as the control drug. Both drugs were administered orally at dosages of 20mg (lower dosage) or 30mg (higher dosage) every 12 hours for 7 days. The parameters for pain assessment were pain intensity, evaluated on a 1 to 10 numerical rating scale, and pain relief (PAR), evaluated on a 5-grade scale.
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页码：34 / 42
页数：8
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