mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity

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作者
Joseph A. Waldron
David C. Tack
Laura E. Ritchey
Sarah L. Gillen
Ania Wilczynska
Ernest Turro
Philip C. Bevilacqua
Sarah M. Assmann
Martin Bushell
John Le Quesne
机构
[1] Cancer Research UK Beatson Institute,Department of Biology
[2] Pennsylvania State University,Department of Chemistry
[3] Pennsylvania State University,Center for RNA Molecular Biology
[4] Present Address: Spectrum Health Office of Research,Present Address: Department of Chemistry
[5] Pennsylvania State University,Department of Haematology
[6] University of Pittsburgh at Johnstown,Medical Research Council Biostatistics Unit
[7] University of Cambridge,Department of Biochemistry & Molecular Biology
[8] Cambridge Institute of Public Health,Medical Research Council Toxicology Unit
[9] National Health Service Blood and Transplant,Leicester Cancer Research Centre
[10] National Institute for Health Research BioResource,undefined
[11] Cambridge University Hospitals,undefined
[12] Pennsylvania State University,undefined
[13] Institute of Cancer Sciences,undefined
[14] University of Glasgow,undefined
[15] University of Cambridge,undefined
[16] University of Leicester,undefined
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关键词
eIF4A; RNA structure; Hippuristanol; Translation; Translation initiation; Cancer; Structure-seq; DMS; Polysome profiling; G-quadruplexes;
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