Dual-adhesive and self-healing alginate-based hydrogel for wound healing

被引:0
|
作者
Naglaa Salem El‑Sayed
Naiera M. Helmy
Samir Kamel
机构
[1] National Research Centre,Cellulose and Paper Department
[2] Biotechnology Research Institute,Microbial Biotechnology Department
[3] National Research Centre,undefined
来源
Chemical Papers | 2024年 / 78卷
关键词
Sodium Alginate; Self-Healing; 9-Aminoacridine; Kanamycin; Interpenetrating and Antimicrobial Hydrogel;
D O I
暂无
中图分类号
学科分类号
摘要
Some of the wound dressings on the market cause skin tearing and bleeding when removed, slowing the healing process. So, it is difficult to treat infected wounds of sensitive skin patients. Herein, antibacterial and biocompatibility self-healing hydrogel loaded with 9-Aminoacridine and kanamycin sulfate were prepared by grafting poly(β-carboxyethyl acrylate-co-acrylamide) onto sodium alginate. The biological assay demonstrated the hydrogels’ good biocompatibility, which showed no harmful effects on normal human melanocyte cells. In addition, the hydrogels had a powerful antibacterial impact on the various bacterial strains utilized in the investigation. From the study of the rheological properties of the prepared hydrogel, it was found that it is a non-Newtonian fluid. These results suggest the possible utilization of the as-prepared hydrogels in the fabrication of wound healing.
引用
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页码:1021 / 1031
页数:10
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