Stability of nanodispersions based on perfluorohydrocarbons and phospholipids

Series of nanodispersions—emulsions with identical compositions based on perfluorohydrocarbons (PFH) and phospholipids (PL) were prepared. Extensive experimental results for the size (~100 nm) and structure of the particles, the viscosity, the pH and pF values, and the osmolarity level showed that the PFH/PL emulsions corresponded to the physicochemical parameters established for medical and biological PFH emulsions. The final drug form of the emulsion (in a vial) withstood thermal sterilization. The PFH/PL emulsions retained their particle size and structure during controlled storage at +4°C to +10°C for 12 months, i.e., the obtained nanodispersion was stable on storage in an unfrozen state for one year.