Binding of Aminoalkylindoles to Noncannabinoid Binding Sites in NG108-15 Cells

被引：0
|
作者：
Sheryl Stark
Mary A. Pacheco
Steven R. Childers
机构：
[1] Wake Forest University,Neuroscience Program and Department of Physiology and Pharmacology, Bowman Gray School of Medicine
[2] University of Florida College of Medicine,Department of Neuroscience
来源：
Cellular and Molecular Neurobiology | 1997年 / 17卷
关键词：
neuroblastoma cells; aminoalklindoles; cannabinoid receptors; Δ; -tetrahydrocannabinol, anandamide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
1. Aminoalkylindoles, typified by WIN 55212-2, bind to G protein-coupled cannabinoid receptors in brain. Although cannabinoids inhibit adenylyl cyclase in NG108-15 neuroblastoma × glioma hybrid cells, cannabinoid receptor binding in these cells has not been described previously. This study compares pharamcological characteristics of [3H]WIN 55212-2 binding sites in rat cerebellar membranes and in NG108-15 membranes.
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页码：483 / 493
页数：10
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