Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

被引：0

作者：

Zhenyu Zhang

Minnan Chen

Wenjing Zhan

Yuechun Chen

Tongtong Wang

Zhonghua Chen

Yifei Fu

Gang Zhao

Dong Mao

Jingjing Ruan

Feng-Lai Yuan

机构：

[1] Affiliated to Jiangnan University,Institute of Integrated Chinese and Western Medicine

[2] Nantong First People’s Hospital, The Key Laboratory of Anti

[3] Anhui Medical University,Inflammatory and Immune Medicine

[4] Wuxi 9th People’s Hospital Affiliated to Soochow University,Orthopaedic Institute

[5] The First Affiliated Hospital of Anhui Medical University,Department of Respiratory and Critical Care Medicine

来源：

Cell Death Discovery | / 9卷

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摘要：

Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca2+‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.

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