Absorption, Metabolism, and Disposition of [14C]SDZ ENA 713, an Acetylcholinesterase Inhibitor, in Minipigs Following Oral, Intravenous, and Dermal Administration

被引：0
|
作者：
Francis L. S. Tse
Robert Laplanche
机构：
[1] Novartis Pharmaceuticals Corporation,Department of Drug Metabolism and Pharmacokinetics, Preclinical Safety
[2] Preclinical Safety,Department of Drug Metabolism and Pharmacokinetics
[3] Novartis Pharma Inc.,undefined
来源：
Pharmaceutical Research | 1998年 / 15卷
关键词：
Alzheimer's disease; rivastigmine; minipig; transdermal absorption; bioavailability; skin abrasion;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. SDZ ENA 713 (rivastigmine) is an acetylcholinesterase inhibitor intended for therapeutic use in Alzheimer's disease. The present study compared the pharmacokinetics of [14C]SDZ ENA 713 after intravenous, oral, and dermal administration to male minipigs, and also examined the effects of dose level and skin abrasion on transdermal absorption.
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页码：1614 / 1620
页数：6
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