Digoxin chronotherapy can modulate myocardial ischemia-reperfusion injury

被引：0
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作者：
不详
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来源：
NATURE CARDIOVASCULAR RESEARCH | 2022年 / 1卷 / 11期
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D O I：
10.1038/s44161-022-00173-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial ischemia-reperfusion injury (MIRI) substantially contributes to the morbidity associated with ischemic heart disease. Timed administration of digoxin decreased the susceptibility of mouse cardiomyocytes to MIRI; digoxin acted by promoting proteasomal degradation of the nuclear receptor REV-ERB alpha, a key component of the molecular circadian clock.
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页码：988 / 989
页数：2
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