Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway

被引：0
|
作者：
Khosrow Siamak Houschyar
Mimi R. Borrelli
Susanne Rein
Christian Tapking
Daniel Popp
Alen Palackic
Behrus Puladi
Mark Ooms
Madeline Houschyar
Ludwik K. Branski
Laurenz Schmitt
Ali Modabber
Albert Rübben
Frank Hölzle
Amir S. Yazdi
机构：
[1] RWTH University Hospital Aachen,Department of Dermatology and Allergology
[2] Stanford School of Medicine,Division of Plastic and Reconstructive Surgery, Department of Surgery
[3] Klinikum St. Georg,Department of Plastic and Hand Surgery
[4] University of Heidelberg,Burn Center
[5] Medical University of Graz,Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen
[6] University Hospital RWTH,Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery
[7] Martin Luther University of Halle,Department of Oral and Maxillofacial Surgery
[8] University of Texas Medical Branch,Institute of Agricultural and Nutrition Sciences
来源：
European Journal of Plastic Surgery | 2022年 / 45卷
关键词：
Stem cells; Carcinoma; Wnt signaling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Squamous cell carcinoma (SCC) of the head and neck region accounts for 3% of all tumors worldwide. The incidence is higher in men, with most carcinomas found in the oral cavity. At the point of initial diagnosis, distant metastases are rare. The Wnt signaling pathway is critically involved in cell development and stemness and has been associated with SCC. Understanding precisely how Wnt signaling regulates SCC progression and how it can, therefore, be modulated for the therapeutic benefit has enormous potential in the treatment of head and neck SCC. In this review, we will describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes both in homeostasis and in the development and progression of SCC.
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页码：863 / 871
页数：8
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