Ultrastructural and Functional Changes in Liver Mitochondria in a Rat Model of Type I Diabetes Mellitus

被引：1
|
作者：
Starinets V.S. [1 ]
Lebedeva E.V. [1 ]
Mikheeva I.B. [2 ]
Belosludtseva N.V. [2 ]
Dubinin M.V. [1 ]
Belosludtsev K.N. [1 ,2 ]
机构：
[1] Mari State University, Yoshkar-Ola
[2] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290, Moscow oblast
来源：
Biophysics | 2019年 / 64卷 / 5期
基金：
俄罗斯基础研究基金会;
关键词：
Keywords: type I diabetes mellitus; mitochondria; mitochondrial respiration; oxidative phosphorylation;
D O I：
10.1134/S0006350919050221
中图分类号：
学科分类号：
摘要：
Abstract—The characteristics of the ultrastructure and functioning of mitochondria in the liver of Sprague Dawley rats in the experimental model of type I diabetes mellitus have been investigated. It has been found that diabetes mellitus induced in response to streptozotocin administration at a dose of 75 mg/kg body weight was accompanied by disturbances in the structural organization of mitochondrial cristae and a decrease in the size of the organelles compared to the control. It has been also demonstrated that in type I diabetes the respiratory rates of liver mitochondria in metabolic states 2, 3, and 4 increase. This may be associated with an increase in the total content of fatty acids in liver mitochondria of diabetic rats. At the same time, streptozotocin-induced diabetes mellitus in rats did not affect the indices of oxidative phosphorylation efficiency (ADP/O, respiratory control ratio, and phosphorylation time) in liver mitochondria. © 2019, Pleiades Publishing, Inc.
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页码：755 / 760
页数：5
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