Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect

被引：0
|
作者：
Christine A. Rabinak
Chandra Sekhar Sripada
Mike Angstadt
Harriet de Wit
K. Luan Phan
机构：
[1] University of Michigan,Department of Psychiatry
[2] University of Michigan,Neuroscience Program
[3] Veterans Affairs Ann Arbor Healthcare System,Mental Health Service
[4] University of Chicago,Department of Psychiatry and Behavioral Neuroscience
来源：
Journal of Neural Transmission | 2012年 / 119卷
关键词：
Cannabinoid; Amygdala; Subgenual anterior cingulate; Emotion; fMRI;
D O I：
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学科分类号：
摘要：
Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆9-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.
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页码：701 / 707
页数：6
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