Polymeric Prodrugs Containing Metal-Based Anticancer Drugs

被引：0
|
作者：
B. A. Aderibigbe
机构：
[1] University of Fort Hare,Department of Chemistry
[2] Alice Campus,undefined
来源：
Journal of Inorganic and Organometallic Polymers and Materials | 2015年 / 25卷
关键词：
Anticancer; Metal complexes; Prodrugs; Medicinal organometallics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Prodrugs optimize the absorption, distribution, metabolism, excretion and reduce unwanted toxicity of the parent drugs. The medicinal application of polymeric prodrugs for delivery of metal-based anticancer drugs is a field of increasing prominence because metal-based drugs offer possibilities for the design of therapeutic agents that are not readily available to organic compounds. This review is focused on the progress of polymeric prodrugs of metal based anticancer agents. A better understanding of the pharmacokinetics of these prodrugs will provide a rational for their further development into anticancer drugs for overcoming multidrug resistance.
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页码：339 / 353
页数：14
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