Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

被引：0
|
作者：
Alberto Bartesaghi
Alan Merk
Mario J Borgnia
Jacqueline L S Milne
Sriram Subramaniam
机构：
[1] Laboratory of Cell Biology,
[2] Center for Cancer Research,undefined
[3] National Cancer Institute,undefined
[4] National Institutes of Health,undefined
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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摘要：
HIV-1 Env glycoprotein binds receptors on the host cells, triggering a conformational change from a closed to an open state. Now single-particle cryo-EM analysis of a soluble, trimeric Env construct reveals the structure of the closed state at ∼6-Å resolution. The structure features three gp41 helices at the center of the trimer, thus indicating that HIV-1 and influenza viruses use similar mechanisms to enter the cell.
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页码：1352 / 1357
页数：5
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