Mainstreaming germline genetic testing for patients with pancreatic cancer increases uptake

被引:0
|
作者
Mitchell L. Ramsey
Jewel Tomlinson
Rachel Pearlman
Laith Abushahin
Amber Aeilts
Hui-Zi Chen
Yan Chen
Ashley Compton
Rifat Elkhatib
Levi Geiger
John Hays
Joanne Jeter
Ning Jin
Pannaga Malalur
Sameek Roychowdhury
Jessica Ruple
Jennifer Prebish
Peter P. Stanich
Heather Hampel
机构
[1] The Ohio State University Wexner Medical Center,Division of Gastroenterology, Hepatology and Nutrition
[2] The Ohio State University Wexner Medical Center,Department of Internal Medicine
[3] The Ohio State University Wexner Medical Center,Division of Medical Oncology
[4] The Ohio State University Comprehensive Cancer Center,undefined
来源
Familial Cancer | 2023年 / 22卷
关键词
BRCA1/2; PALB2; Pancreatic ductal adenocarcinoma; Healthcare delivery;
D O I
暂无
中图分类号
学科分类号
摘要
Germline genetic testing is recommended for all patients with pancreatic cancer (PC) but uptake rates are low. We implemented a mainstreaming program in oncology clinics to increase testing for PC patients. Genetic counselors trained oncology providers to offer a standardized multigene panel and obtain informed consent using an educational video. Pre-test genetic counseling was available upon request. Otherwise, patients with identified pathogenic variants, strong family history, or questions regarding their results were referred for post-test genetic counseling. We measured rates of testing and genetic counseling visits. From September 2019 to April 2021, 245 patients with PC underwent genetic testing. This represents a 6.5-fold increase in germline testing volume (95% confidence interval 5.2–8.1) compared to previous years. At least one pathogenic or likely pathogenic variant (PV/LPV) was found in 34 (13.9%) patients, including 17 (6.9%) PV/LPVs in high or moderate risk genes and 18 (7.3%) in low risk or recessive genes. Five (2.0%) PVs had implications on treatment selection. 22 of the positive patients (64.7%) and an additional 8 PC patients (1 negative, 3 VUS, and 4 pre-test) underwent genetic counseling during the study period. Genetic counselors saw 2.0 PC patients/month prior to this project, 1.6 PC patients/month during this project, and would have seen 2.2 PC patients/month if all patients with pathogenic variants attended post-test counseling. Conclusions Mainstreaming genetic testing expands access for PC patients without overwhelming genetic counseling resources.
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页码:91 / 97
页数:6
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