Endothelial metalloprotease-disintegrin protein (ADAM) is implicated in angiogenesis in vitro

被引：22

作者：

Trochon V. ^{[1
,2
,7
]}

Li H. ^{[2
,3
]}

Vasse M. ^{[2
]}

Frankenne F. ^{[4
]}

Thomaidis A. ^{[1
]}

Soria J. ^{[5
]}

Lu H. ^{[1
]}

Gardner C. ^{[6
]}

Soria C. ^{[1
,2
]}

机构：

[1] Inserm U353, Institut d'Hématologie, Univ. Paris 7-Denis Diderot, F-75475 Paris Cedex 10

[2] Laboratoire DIFEMA, Fac. de Med. et de Pharm. de Rouen, Rouen

[3] Le Ctr. Natl. de la Rech. Sci., UMR 1582, Institut Gustave Roussy

[4] Lab. Biol. des Tumeurs et du Devmt., Liège

[5] Laboratoires Biochmie Sainte Marie, Hôtel Dieu, Paris

[6] HoechstMarion-Roussel, F-93235 Romainville

[7] INSERM U 353, Bat INSERM, Hôpital Saint Louis, F-75475, Paris Cedex 10

来源：

Angiogenesis | 1998年 / 2卷 / 3期

关键词：

ADAM/MDC; Angiogenesis; Endothelial cells;

D O I：

10.1023/A:1009206817829

中图分类号：

学科分类号：

摘要：

Recently two metalloproteinase, disintegrin, cysteine proteins (MDCs), also called ADAMs were identified on endothelial cells. However the role of these ADAMs are not defined on these cells. In order to elucidate whether ADAMs associated with endothelial cells could be involved in angiogenesis, we have tested the effect of an inhibitor of ADAM (GL 129471) in models of angiogenesis in vitro. Our results showed that GL 129471 inhibited endothelial cell migration and adhesion and increased the number of cells in the G2/M phase leading to an inhibition of cell proliferation. The effects of GL 129471 are not mimicked by the endogenous matrix metalloproteinase inhibitor TIMP-2. These data suggest that ADAMs may play important role in angiogenesis and could provide a new target for inhibition of angiogenesis in cancers.

引用

页码：277 / 285

页数：8

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