Oral and intravenous pharmacokinetics of 5-fluoro-2′-deoxycytidine and THU in cynomolgus monkeys and humans

被引:0
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作者
Julianne L. Holleran
Jan H. Beumer
David L. McCormick
William D. Johnson
Edward M. Newman
James H. Doroshow
Shivaani Kummar
Joseph M. Covey
Myrtle Davis
Julie L. Eiseman
机构
[1] University of Pittsburgh,Cancer Therapeutics Program, University of Pittsburgh Cancer Institute
[2] University of Pittsburgh,Department of Pharmaceutical Sciences, School of Pharmacy
[3] University of Pittsburgh,Department of Medicine, School of Medicine
[4] IIT Research Institute,Department of Cancer Biology
[5] City of Hope Beckman Research Institute,Division of Cancer Treatment and Diagnosis
[6] NCI,Department of Pharmacology and Chemical Biology, School of Medicine
[7] NIH,undefined
[8] University of Pittsburgh,undefined
[9] University of Pittsburgh Cancer Institute,undefined
[10] University of Pittsburgh Cancer Institute,undefined
来源
关键词
Fluorodeoxycytidine; Tetrahydrouridine; Toxicokinetics; Toxicity; Monkeys; DNA methylation inhibitor;
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学科分类号
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页码:803 / 811
页数:8
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