Monitoring metabolism of synthetic cannabinoid 4F-MDMB-BINACA via high-resolution mass spectrometry assessed in cultured hepatoma cell line, fungus, liver microsomes and confirmed using urine samples

被引：0
|
作者：
Huey Sze Leong
Shimpei Watanabe
Unnikrishnan Kuzhiumparambil
Ching Yee Fong
Hooi Yan Moy
Yi Ju Yao
Paul K. Witting
Shanlin Fu
机构：
[1] University of Technology Sydney,Centre for Forensic Science, School of Mathematical and Physical Sciences
[2] The University of Sydney,Discipline of Pathology, Faculty of Medicine and Health, The Charles Perkins Centre
[3] Linköping University,Division of Drug Research, Department of Biomedical and Clinical Sciences
[4] National Board of Forensic Medicine,Deparment of Forensic Genetics and Forensic Toxicology
[5] University of Technology Sydney,Climate Change Cluster
[6] Health Sciences Authority,Analytical Toxicology Laboratory, Applied Sciences Group
[7] Photon Science Research Division,Forensic Science Group
[8] RIKEN,undefined
来源：
Forensic Toxicology | 2021年 / 39卷
关键词：
4F-MDMB-BINACA metabolism; 4F-MDMB-BUTINACA (4F-ADB); HepG2; Human liver microsomes; Urinary marker of 4F-MDMB-BINACA intake;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：198 / 212
页数：14
相关论文
共 17 条
  • [1] Monitoring metabolism of synthetic cannabinoid 4F-MDMB-BINACA via high-resolution mass spectrometry assessed in cultured hepatoma cell line, fungus, liver microsomes and confirmed using urine samples
    Leong, Huey Sze
    Watanabe, Shimpei
    Kuzhiumparambil, Unnikrishnan
    Fong, Ching Yee
    Moy, Hooi Yan
    Yao, Yi Ju
    Witting, Paul K.
    Fu, Shanlin
    [J]. FORENSIC TOXICOLOGY, 2021, 39 (01) : 198 - 212
  • [2] Detection of metabolites of the new synthetic cannabinoid CUMYL-4CN-BINACA in authentic urine samples and human liver microsomes using high-resolution mass spectrometry
    Ozturk, Yeter Erol
    Yeter, Oya
    Ozturk, Serkan
    Karakus, Goksun
    Ates, Ismail
    Buyuk, Yalcin
    Yurdun, Turkan
    [J]. DRUG TESTING AND ANALYSIS, 2018, 10 (03) : 449 - 459
  • [3] Metabolic profiling of synthetic cannabinoid 5F-ADB by human liver microsome incubations and urine samples using high-resolution mass spectrometry
    Yeter, Oya
    Ozturk, Yeter Erol
    [J]. DRUG TESTING AND ANALYSIS, 2019, 11 (06) : 847 - 858
  • [4] In vitro Phase I metabolism of indazole carboxamide synthetic cannabinoid MDMB-CHMINACA via human liver microsome incubation and high-resolution mass spectrometry
    Presley, Brandon C.
    Logan, Barry K.
    Jansen-Varnum, Susan A.
    [J]. DRUG TESTING AND ANALYSIS, 2019, 11 (08) : 1264 - 1276
  • [5] Identifying Metabolites of Meclonazepam by High-Resolution Mass Spectrometry Using Human Liver Microsomes, Hepatocytes, a Mouse Model, and Authentic Urine Samples
    Vikingsson, Svante
    Wohlfarth, Ariane
    Andersson, Mikael
    Green, Henrik
    Roman, Markus
    Josefsson, Martin
    Kugelberg, Fredrik C.
    Kronstrand, Robert
    [J]. AAPS JOURNAL, 2017, 19 (03): : 736 - 742
  • [6] Identifying Metabolites of Meclonazepam by High-Resolution Mass Spectrometry Using Human Liver Microsomes, Hepatocytes, a Mouse Model, and Authentic Urine Samples
    Svante Vikingsson
    Ariane Wohlfarth
    Mikael Andersson
    Henrik Gréen
    Markus Roman
    Martin Josefsson
    Fredrik C Kugelberg
    Robert Kronstrand
    [J]. The AAPS Journal, 2017, 19 : 736 - 742
  • [7] In vitro metabolism of synthetic cannabinoid AM1220 by human liver microsomes and Cunninghamella elegans using liquid chromatography coupled with high resolution mass spectrometry
    Shimpei Watanabe
    Unnikrishnan Kuzhiumparambil
    Shanlin Fu
    [J]. Forensic Toxicology, 2018, 36 : 435 - 446
  • [8] In vitro metabolism of synthetic cannabinoid AM1220 by human liver microsomes and Cunninghamella elegans using liquid chromatography coupled with high resolution mass spectrometry
    Watanabe, Shimpei
    Kuzhiumparambil, Unnikrishnan
    Fu, Shanlin
    [J]. FORENSIC TOXICOLOGY, 2018, 36 (02) : 435 - 446
  • [9] Metabolites of 5F-AKB-48, a synthetic cannabinoid receptor agonist, identified in human urine and liver microsomal preparations using liquid chromatography high-resolution mass spectrometry
    Holm, Niels Bjerre
    Pedersen, Anders Just
    Dalsgaard, Petur Weihe
    Linnet, Kristian
    [J]. DRUG TESTING AND ANALYSIS, 2015, 7 (03) : 199 - 206
  • [10] Characterization of 3-Hydroxyeticyclidine (3-HO-PCE) Metabolism in Human Liver Microsomes and Biological Samples Using High-Resolution Mass Spectrometry
    Larabi, Islam Amine
    Joseph, Delphine
    Lesueur, Camille
    Alvarez, Jean-Claude
    [J]. METABOLITES, 2023, 13 (03)
12