snoRNAs contribute to myeloid leukaemogenesis

被引：0
|
作者：
Mona Khalaj
Christopher Y. Park
机构：
[1] NYU School of Medicine,Department of Pathology
[2] Weill Graduate School of Medical Sciences,undefined
[3] Cornell University,undefined
[4] Memorial Sloan Kettering Cancer Center,undefined
来源：
Nature Cell Biology | 2017年 / 19卷
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摘要：
The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.
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页码：758 / 760
页数：2
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