Synthesis and Anti-inflammatory, Analgesic, and Antipyretic Activities of Azomethine Derivatives of the Tetrahydropyran Series

被引：0
|
作者：
Isakhanyan, A. U. [1 ]
Hakobyan, N. Z. [1 ]
Muradyan, R. E. [1 ]
Tumajyan, H. E. [1 ]
Panosyan, H. A. [1 ]
Harutyunyan, A. A. [1 ]
机构：
[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 03期
关键词：
Schiff bases; amines; condensation; tetrahydropyran series; anti-inflammatory activity; carrageenan-induced and chronic inflammation;
D O I：
10.1134/S1070428024030230
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Schiff bases of the tetrahydropyran series have been synthesized by the condensation of 2-(tetrahydropyran-4-yl)ethanamines and tetrahydropyran-4-amine with 4-chloro, 4-fluoro-, and 4-(dimethylamino)-benzaldehydes and thiophene-2-carbaldehyde. The synthesized compounds showed lower anti-inflammatory, analgesic, and antipyretic activities than those of diclofenac and indomethacin used as reference drugs.
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页码：539 / 542
页数：4
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