Self-Assembling DNA-Lipid Particles for Gene Transfer

被引：0
|
作者：
Yuan-Peng Zhang
Dorothy L. Reimer
Guoyang Zhang
Patricia H. Lee
Marcel B. Bally
机构：
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
gene transfer; cationic lipid; DNA complexes; hydrophobic effect;
D O I：
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学科分类号：
摘要：
Purpose. We have demonstrated that a heteromolecular complex consisting of cationic lipids and DNA can be prepared and isolated (1). Cationic lipids bind DNA through electrostatic interactions. However, when sufficient lipids are bound to DNA the physical and chemical properties of the complex are governed by hydrophobic effects. Here we describe an approach where this hydrophobic complex is used as an intermediate in the preparation of lipid-DNA particles (LDPs).
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页码：190 / 196
页数：6
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